Polyanionic Hydrogels as Reservoirs for Polycationic Antibiotic Substitutes Providing Prolonged Antibacterial Activity

A recent article on one of our hydrogel based formulations and their use in combination with woundcare products against multiple infections. In collaboration with INSERM UMR 1121. Implantation of biomedical devices is often followed by bacterial infections that may seriously affect implant functionalities and lead to their failure.  Antibiotic resistance is a problem that is spreading very rapidly in hospitals around the world. One solution to this problem is the development of antimicrobial coatings based on biopolymers: hyaluronic acid (HA) and polyarginine (PAR).

We introduce a new formulation of hyaluronic acid (HA)-based antimicrobial material: HA hydrogels loaded with polyarginine (PAR), a polycationic antibiotic substitute. The loading is possible through electrostatic interactions between negatively charged HA and positively charged PAR. Such hydrogels absorb high quantities of PAR, which are then gradually released from the hydrogel. This original system provides a long-lasting antibacterial effect on an in vitro model of repetitive infection, thus demonstrating a strong potential to fight multiple rounds of infections that are resistant to antibiotic treatment. This technology is intended to be deposited on medical devices such as orthopaedic prostheses for example.

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